Dr. Alan Hammer 

Breast cancer is one of the leading causes of cancer-related deaths in females and the mortality rate of breast cancer increases upon tumor metastasis.  Breast cancer cells synthesize and locally secrete the hormone prolactin (PRL) and express high levels of the PRL receptor (PRL-R).  Additionally, metastatic breast tumors have increased activity of the serine/threonine kinase PAK1.  Importantly, PRL can mediate PAK1 activity through the non-receptor tyrosine kinase JAK2.  JAK2 can phosphorylate PAK1 on three...